OCH, CAS [[383187-82-4]], Unconjugated

Product Overview

• Article Name: OCH, CAS [[383187-82-4]], Unconjugated
• Biozol Catalog Number: BSS-BS-75502C
• Supplier Catalog Number: bs-75502C
• Alternative Catalog Number: BSS-BS-75502C-1,BSS-BS-75502C-250
• Manufacturer: Bioss
• Category: Biochemikalien
• Conjugation: Unconjugated

Product Description

Truncated analog of alpha-GalCer. iNKT cell glycolipid agonist. Immunosuppressive. Th2 polarizing. Stimulation of NKT with OCH results in release of primarily Th2 cytokine compared to stimulation with alpha-GalCer, which results in release of a mixture of Th1 and Th2 cytokines. Induces stronger interleukin-4 (IL-4) secretion and weaker interferon-gamma (IFN-gamma) secretion than alpha-GalCer both in vitro and in vivo. Inducer of interleukin-10 (IL-10) and suppressor of diabetes. Shown to prevent experimental autoimmune encephalomyelitis (EAE) in mice, an animal model of multiple sclerosis. Has beneficial effects on type I diabetes in NOD mice. Suppressor of collagen-induced arthritis. Might be useful for immunotherapy of transplant rejection.

Product Properties

• Buffer: Solid
• CAS Number: [383187-82-4]