2,5-Dimethyl-celecoxib, CAS [[457639-26-8]], Unconjugated

Product Overview

• Article Name: 2,5-Dimethyl-celecoxib, CAS [[457639-26-8]], Unconjugated
• Biozol Catalog Number: BSS-BS-75508C
• Supplier Catalog Number: bs-75508C
• Alternative Catalog Number: BSS-BS-75508C-5,BSS-BS-75508C-25
• Manufacturer: Bioss
• Category: Biochemikalien
• Conjugation: Unconjugated

Product Description

Close structural analog of the selective cyclooxygenase-2 (COX-2) inhibitor celecoxib, that lacks COX-2 inhibitory function. Anti-proliferative, anti-tumorigenic and anti-angiogenic. Potent apoptosis inducer in many cancer cell lines. Down-regulates the expression of survivin, cyclins, MMPs and inhibits cyclin-dependent kinase activity. Modulates PDK-1, AKT, GSK3beta, p70 S6K, PKA and MAPKAP-K1alpha. Reduces phosphorylation of ERK1/2 but not AKT T-308 or AKT S-473. Increases intracellular free calcium levels and potently triggers the endoplasmatic reticulum stress response (ESR), activating ER stress-associated proteins GRP78/BiP, CHOP/GADD153 and caspase-4.

Product Properties

• Buffer: Solid
• CAS Number: [457639-26-8]