RF-22c [5-Lipoxygenase Inhibitor], CAS [[1680206-61-4]], Unconjugated

Product Overview

• Article Name: RF-22c [5-Lipoxygenase Inhibitor], CAS [[1680206-61-4]], Unconjugated
• Biozol Catalog Number: BSS-BS-75545C
• Supplier Catalog Number: bs-75545C
• Alternative Catalog Number: BSS-BS-75545C-2
• Manufacturer: Bioss
• Category: Biochemikalien
• Conjugation: Unconjugated

Product Description

Selective and reversible potent inhibitor of human 5-lipoxygenase (5-LO). This enzyme catalyzes two initial steps in the conversion of arachidonic acid into leukotrienes, well known mediators of inflammatory and allergic reactions. Potently inhibits 5-LO product synthesis intact human leukocytes, such as neutrophils and monocytes (IC50>22nM) and in cell-free assays (IC50>140nM) without affecting 12/15-LOs, cyclooxygenase (COX)-1/2 or arachidonic acid release. Anti-inflammatory compound. Shows pronounced effectiveness in different models of inflammation in vivo at 0.1 mg/kg, i.p. Impaired (I) bronchoconstriction in ovalbumin-sensitized mice challenged with acetylcholine, (II) exudate formation in carrageenan-induced paw edema and (III) zymosan-induced leukocyte infiltration in air pouches.

Product Properties

• Buffer: Solid
• CAS Number: [1680206-61-4]