MI-2 [MALT1 Inhibitor], CAS [[1047953-91-2]], Unconjugated

Product Overview

• Article Name: MI-2 [MALT1 Inhibitor], CAS [[1047953-91-2]], Unconjugated
• Biozol Catalog Number: BSS-BS-75553C
• Supplier Catalog Number: bs-75553C
• Alternative Catalog Number: BSS-BS-75553C-5,BSS-BS-75553C-25
• Manufacturer: Bioss
• Category: Biochemikalien
• Conjugation: Unconjugated

Product Description

Highly potent and selective irreversible MALT1 inhibitor (IC50=5.8µM). Binds directly to MALT1 and suppresses protease function. Decreases NF-kappaB activity induced by MALT1. Inhibits cell proliferation and MALT1-mediated cleavage activity. Suppresses human TMD8 and HBL-1 (EC50= ~200nM and ~500nM for HBL-1 and TMD8, respectively) activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL) cell lines in vitro and xenotransplanted mouse ABC-DLBCL tumors in vivo and primary human ABC-DLBCLs ex vivo. In combination with bryostatin 1 displays selective killing of HIV latently infected CD4+ T cells. Inhibits NF-kappaB and NLRP3 inflammasome activation in macrophages. Decreased production of IL-1beta/IL-18 in PMA-differentiated THP-1 cells and bone marrow derived macrophage via suppressing the activation of NF-kappaB and NLRP3 inflammasome.

Product Properties

• Buffer: Solid
• CAS Number: [1047953-91-2]