Carfilzomib [PR-171], CAS [[868540-17-4]], Unconjugated

Product Overview

• Article Name: Carfilzomib [PR-171], CAS [[868540-17-4]], Unconjugated
• Biozol Catalog Number: BSS-BS-75558C
• Supplier Catalog Number: bs-75558C
• Alternative Catalog Number: BSS-BS-75558C-1,BSS-BS-75558C-5,BSS-BS-75558C-25
• Manufacturer: Bioss
• Category: Biochemikalien
• Conjugation: Unconjugated

Product Description

Potent and irreversible second-generation peptide epoxyketone class proteasome inhibitor. Synthetic analog of the microbial product epoxomicin (Prod. No. bs-75199C). Targets the chymotrypsin-like beta5 subunit of the constitutive 20S proteasome (IC50=5.2nM) and the beta5i subunit [LMP7] of the 20S immunoproteasome (IC50=14nM), with minimal cross-reactivity to other proteases. Displays equal potency but greater selectivity for the chymotrypsin-like activity of the proteasome compared to bortezomib (Prod. No. bs-75509C). Anticancer compound effective against multiple myeloma in vivo. In vitro, induces cell cycle arrest and apoptosis in human cancer cell lines including multiple myeloma, lymphoma and various solid tumors (IC50s=2.4-20nM).

Product Properties

• Buffer: Solid
• CAS Number: [868540-17-4]