Cell senescence related gene complementation group B, Cellular senescence related protein 1, CSR, CSRB, MORF 4, MORF4, MORF4 protein, Mortality factor 4, SEN 1, SEN, Senescence cellular related 1, Senescence related cellular 1, Transcription factor like protein MORF4, MO4L1_HUMAN, Mortality factor 4-like protein 1, MORF-related gene 15 protein, Protein MSL3-1, Transcription factor-like protein MRG15.
Cellular senescence, the terminal nondividing state that normal cells enter following completion of their proliferative potential, is the dominant phenotype in hybrids of normal and immortal cells. Fusions of immortal human cell lines with each other have led to their assignment to one of several complementation groups. SEN1 or MORF4 is a gene on chromosome 4 that induces a senescent-like phenotype in cell lines assigned to complementation group B. It is capable of reversing the immortal phenotype of a subset of immortal cells. Overexpression of SEN1 in HeLa cells ultimately caused abnormal nuclear morphology and cell death.
