Activator of G-protein signaling 3,AGS3,AGS3 homolog,C10a,G protein signaling modulator 1 AGS3 like, C. elegans,G-protein-signaling modulator 1,GPSM1,GPSM1_HUMAN.
Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction.
