Y-linked, F-box-like/WD repeat-containing protein TBL1Y, TBL1, TBL1Y, TBL1Y_HUMAN, Transducin beta like 1, Y linked, Transducin beta-like 1, Transducin beta-like protein 1Y, Transducin-beta-like protein 1, Transducin-beta-like protein 1, Y-linked.
FunctionF-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange.
