NDRD, RRD, AI043103, AI790593, Carbonyl reductase, CR, D14Ucla2, Dehydrogenase/reductase SDR family member 4, Dhrs4, DHRS4_HUMAN, humNRDR antibody NADPH dependent carbonyl reductase/NADP retinol dehydrogenase, NADPH dependent retinol dehydrogenase/reductase, NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase, NADPH-dependent retinol dehydrogenase/reductase, NRDR, Peroxisomal short chain alcohol dehydrogenase, Peroxisomal short-chain alcohol dehydrogenase, PHCR, PRO1800, PSCD, SCAD-SRL, SCADSRL, Short chain dehydrogenase/reductase family member 4, Short-chain dehydrogenase/reductase family member 4, UNQ851.
Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones.Tissue specificity:Isoform 1 is predominantly expressed in normal cervix (at protein level). Isoform 4 is expressed in some neoplastic cervical tissues, but not in normal cervix (at protein level). Isoform 5 and isoform 6 are expressed in a few neoplastic cervical tissues.
