Ecadherin binding protein E7 Antibody, PE Conjugated, Rabbit, Polyclonal
Biozol Catalog Number:
BSS-BS-8386R-PE
Supplier Catalog Number:
bs-8386R-PE
Alternative Catalog Number:
BSS-BS-8386R-PE-100
Manufacturer:
Bioss
Host:
Rabbit
Category:
Antikörper
Application:
IF, WB
Conjugation:
PE
Alternative Names:
c-Cbl-like protein 1, CasBrM murine ecotropic retroviral transforming sequencelike 1, Casitas B-lineage lymphoma transforming sequence-like protein 1, Casitas B-lineage lymphoma-like 1, Casitas B-lineage lymphoma-transforming sequence-like protein 1, cbll1, E3 ubiquitin-protein ligase Hakai, Ecadherin binding protein E7, FLJ23109, HAKAI, HAKAI_HUMAN, MGC163403, OTTHUMP00000206720, OTTHUMP00000206722, OTTHUMP00000206724, RING finger protein 188, RNF188, MGC163401.
CBLL1, also known as HAKAI (meaning destruction? in Japanese), or RNF188 (RING finger protein 188), is a 491 amino acid protein that contains one C2H2-type zinc finger and one RING-type zinc finger. CBLL1 is believed to function as an E3 ubiquitin-protein ligase that accepts a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and immediately transfers that residue to a protein that is targeted for degradation. More specifically, upon activation of c-Src, CBLL1 interacts with and ubiquitinates tyrosine-phosphorylated E-cadherin, thereby targeting the E-cadherin complex for endocytosis and disrupting epithelial cell-cell contacts. Via its role as an E-cadherin regulator, CBLL1 participates in cell adhesion and may also be involved in the regulation of epithelial-mesenchymal transitions.
