C type lectin domain family 4 member E, C type lectin superfamily member 9, C-type calcium dependent carbohydrate recognition domain lectin superfamily member 9, C-type lectin domain family 4 member E, C-type lectin superfamily member 9, CLC4E_HUMAN, CLEC 4E, CLEC4E Clec4e, CLECSF9, Macrophage inducible C type lectin, Macrophage-inducible C-type lectin, MINCLE.
C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B.
