DR1 protein Polyclonal Antibody, AbBy Fluor-680 Conjugated, BF680, Rabbit
Biozol Catalog Number:
BSS-BS-9055R-BF680
Supplier Catalog Number:
bs-9055R-BF680
Alternative Catalog Number:
BSS-BS-9055R-BF680-100
Manufacturer:
Bioss
Host:
Rabbit
Category:
Antikörper
Application:
IF, WB
Species Reactivity:
Human, Mouse, Rat
Conjugation:
BF680
Alternative Names:
Dr1 protein, NC2, Negative cofactor 2 beta, Down regulator of transcription 1, Down regulator of transcription 1 TBP binding, Down-regulator of transcription 1, DR 1, Dr1, NC 2, NC2 beta, NC2-beta, NC2B_HUMAN, Negative co factor 2, Negative cofactor 2, Negative cofactor 2-beta, Protein Dr1, TATA binding protein associated phosphoprotein, TATA-binding protein-associated phosphoprotein.
DR1, also known as NC2 (negative cofactor 2 subunit ), is a TFIID (TATA box-binding protein)-associated protein. DR1 localizes to the nucleus and contains an N-terminal histone fold motif, a TFIID-binding domain and an alanine and glutamine rich region. Via its histone fold motif, DR1 forms a heterodimer with NC2a (DRAP1) to comprise the conserved eukaryotic complex, NC2 (negative cofactor 2). The NC2 complex can both positively and negatively regulate transcription by RNA Pol II. More specifically, NC2 acts as a repressor of TATA-dependent transcription and acts as an activator for DPE-dependent transcription. NC2 represses RNA Pol II transcription by binding to TFIID and inhibiting association of the transcription factors TFIIA and TFIIB. NC2 activity is regulated by phosphorylation. Both subunits, NC2a and DR1, are phosphorylated in vivo.
