GLUP, Molecular chaperone/chaperonin binding protein, PARK 2 co regulated, PARK 2 coregulated, PARK2 co regulated, PARK2 coregulated, PARK2CRG, Parkin co regulated gene protein, Parkin Co-regulated Gene, Parkin coregulated gene protein, RP3 495O10.2, PACRG_HUMAN.
The deduced 257 amino acid protein PACRG (Parkin co-regulated gene) shows potential links to the ubiquitin/proteasome system. PACRG and Parkin are attached in a head-to-head arrangement on opposite DNA strands and share a common 5 flanking promoter region. The PACRG gene maps to chromosome 6q26, Northern blot analysis detects PACRG expression in all tissues examined except placenta. Using a positional cloning strategy in 197 Vietnamese leprosy simplex families (i.e. families with two unaffected parents and one affected child), significant connections between leprosy and 17 markers in the 5 regulatory region that PARK2 and PACRG share were observed. Possession of two or more of the 17 risk alleles is highly predictive of leprosy.PACRG is a gene located very close to parkin, in reverse orientation on the chromosome. It is thought to be co-transcribed with parkin by a bi-directional promoter between the two genes.
