Phospho-BLNK (Tyr189) Polyclonal Antibody, Unconjugated, Rabbit

Product Overview

• Article Name: Phospho-BLNK (Tyr189) Polyclonal Antibody, Unconjugated, Rabbit
• Biozol Catalog Number: BSS-BS-9688R
• Supplier Catalog Number: bs-9688R
• Alternative Catalog Number: BSS-BS-9688R-100
• Manufacturer: Bioss
• Host: Rabbit
• Category: Antikörper
• Application: IF, IHC-P, WB
• Species Reactivity: Human, Mouse
• Conjugation: Unconjugated
• Alternative Names: BLNK phospho Y491, p-BLNK phospho Y491, B cell adapter containing SH2 domain protein, B cell adapter containing Src homology 2 domain protein, B cell linker, B cell linker protein, B cell linker protein, B-cell adapter containing a SH2 domain protein, B-cell adapter containing a Src homology 2 domain protein, B-cell linker protein, BASH, BASH, Bca, Bca, BLNK, BLNK s, BLNK_HUMAN, Cytoplasmic adapter protein, Ly 57, Ly-57, Ly57, Lymphocyte antigen 57, Lymphocyte antigen-57, Lyw 57, Lyw-57, Lyw57, MGC111051, SLP 65, SLP65, SLP-65, Src homology 2 domain containing leukocyte protein of 65 kDa.

Product Description

This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012].

Product Properties

• Clonality: Polyclonal
• Concentration: 1ug/ul
• NCBI: 29760
• Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
• Source: KLH conjugated synthetic phosphopeptide derived from human BLNK around the phosphorylation site of Tyr189 [EN(p-Y)IH]
• Target: Phospho-BLNK (Tyr189)

Application Notes

• Application Dilute: WB(1:300-5000), IHC-P(1:200-400), IF(IHC-P)(1:50-200)