NHA2, Mitochondrial Na+/H+ exchanger NHA2, Mitochondrial sodium/hydrogen exchanger NHA2, Na+/H+ exchanger like domain containing protein 2, Na+/H+ exchanger domain containing 2, NHE domain containing protein 2, NHE10, NHEDC 2, Sodium/hydrogen exchanger like domain containing protein 2, SL9B2_HUMAN.
Na+/H+ exchangers (NHEs) catalyze the transport of Na+ in exchange for H+ across membranes in organisms and are required for numerous physiological processes. NHEDC2 (Na+/H+ exchanger-like domain-containing protein 2), also known as NHA2, is a 537 amino acid mitochondrial protein. NHEDC2 is involved in organelle volume homeostasis by catalyzing the exchange of protons for Na+ and Li+ across the inner mitochondrial membrane. Found in red blood cells, NHEDC2 is required for bone resorption activity and osteoclast differentiation. As a multi-pass membrane protein, NHEDC2 is expressed as two isoforms produced by alternative splicing events.
