Neutrophil Bactericidal Protein BP30, Bactericidal permeability-increasing protein, Bactericidal/permeability increasing protein, BPI, BPI_HUMAN, CAP 57, CAP-57, CAP57.
The cytotoxic action of BPI is limited to many species of Gram-negative bacteria, this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.
