CDKN1B/p27 KIP 1 Monoclonal Antibody, Biotin Conjugated, Clone: [1A7], Mouse

Product Overview

• Article Name: CDKN1B/p27 KIP 1 Monoclonal Antibody, Biotin Conjugated, Clone: [1A7], Mouse
• Biozol Catalog Number: BSS-BSM-33425M-BIOTIN
• Supplier Catalog Number: bsm-33425M-Biotin
• Alternative Catalog Number: BSS-BSM-33425M-BIOTIN-100
• Manufacturer: Bioss
• Host: Mouse
• Category: Antikörper
• Application: IHC-Fr, IHC-P
• Species Reactivity: Human
• Conjugation: Biotin
• Alternative Names: p27 KIP 1, CDN1B_HUMAN, AA408329, AI843786, Cdki1b, CDKN 1B, CDKN 4, CDKN1B, CDKN1B, CDKN4, CDKN4, Cyclin Dependent Kinase Inhibitor 1B, Cyclin Dependent Kinase Inhibitor 1B, Cyclin dependent kinase inhibitor p27, Cyclin dependent kinase inhibitor p27, Cyclin-dependent kinase inhibitor 1B (p27, Kip1), Cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinase inhibitor p27, Cyclin-dependent kinase inhibitor p27 Kip1, KIP 1, KIP1, MEN1B, MEN4, OTTHUMP00000195098, OTTHUMP00000195099, p27, p27 Kip1, P27-like cyclin-dependent kinase inhibitor, P27KIP1.

Product Description

Cell cycle progression is regulated by cyclins and their cognate Cdks. p27 KIP 1 is a cell cycle regulatory mitotic inhibitor of cdk activity. p27 KIP 1 is a candidate tumor suppressor gene, and has been proposed to function as a possible mediator of TGF beta induced G1 arrest. p27 KIP 1 is up regulated in response to antimitogenic stimuli. The increased protein expression of p27 results in cellular arrest by binding to cyclin/Cdk complexes such as cyclin D1/Cdk4. p27 Kip1 is regulated by phosphorylation on serine 10 (S10) and threonine 187 (T187). Phosphorylation by CDK2 on T187 results in ubiquitylation and degradation of p27 Kip 1, while phosphorylation by hKIS on S10 signals the nuclear export to the cytoplasm.

Product Properties

• Clonality: Monoclonal
• Concentration: 1ug/ul
• Clone Designation: [1A7]
• NCBI: 1027
• UniProt: P46527
• Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
• Source: Recombinant human CDKN1B
• Target: CDKN1B/p27 KIP 1

Application Notes

• Application Dilute: IHC-P(1:200-400), IHC-F(1:100-500)