ASBABP2, Aspecific BCL2 ARE binding protein 2, Differentially placenta 1 expressed protein, DIPLA1, IGF dependent IGFBP 4 protease, IGF-dependent IGFBP-4 protease, IGFBP 4ase, IGFBP-4ase, IGFBP4ase, Insulin like growth factor dependent IGF binding protein 4 protease, Insulin-like growth factor-dependent IGF-binding protein 4 protease, PAPA, PAPP A, PAPP-A, PAPP1_HUMAN, PAPPA, PAPPA1, Pappalysin 1 precursor, Pappalysin-1, Pregnancy Associated Plasma Protein A, Pregnancy associated plasma protein A pappalysin 1, Pregnancy-associated plasma protein A.
Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.
