Alcohol sulfotransferase, EC 2.8.2.2, HSST2, Hydroxysteroid sulfotransferase 2, ST2B1, ST2B1_HUMAN, Sulfotransferase 2B1, Sulfotransferase family cytosolic 2B member 1, SULT2B1a, SULT2B1b.
Catalyzes the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol.
