NR3C1, GCR_HUMAN, Glucocorticoid receptor isoform alpha, GCCR, GCR, GR, GRL, Grl1, Nuclear receptor subfamily 3 group C member 1, Glucocorticoid receptor lymphocyte.
Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation. Involved in nuclear translocation.
