MLKL Recombinant Antibody, Biotin Conjugated, Rabbit

Product Overview

• Article Name: MLKL Recombinant Antibody, Biotin Conjugated, Rabbit
• Biozol Catalog Number: BSS-BSM-52256R-BIOTIN
• Supplier Catalog Number: bsm-52256R-Biotin
• Alternative Catalog Number: BSS-BSM-52256R-BIOTIN-100
• Manufacturer: Bioss
• Host: Rabbit
• Category: Antikörper
• Application: WB
• Species Reactivity: Human
• Conjugation: Biotin
• Alternative Names: Mixed lineage kinase domain-like protein, hMLKL, MLKL

Product Description

Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). Binds to highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which is essential for its necroptotic function (PubMed:29883610).

Product Properties

• Clonality: Recombinant
• Concentration: Lot dependent
• NCBI: 197259
• UniProt: Q8NB16
• Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
• Source: Human MLKL between 350 to C-terminus
• Target: MLKL

Application Notes

• Application Dilute: WB(1:300-5000)