NFKBIA, Inhibitor of KB alpha, I kappa B alpha, I(Kappa)B(alpha), IkappaBalpha, IKBA, IKBalpha, MAD 3, MAD3, Major histocompatibility complex enhancer binding protein MAD3, NF kappa B inhibitor alpha, NFKBI, Nuclear factor of kappa light chain gene enhancer in B cells, Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor alpha, IKBA_HUMAN, IkappaB-alpha, IkappaBalpha.
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
