Human IgD Recombinant Antibody, Unconjugated, Rabbit
Biozol Catalog Number:
BSS-BSM-60908R
Supplier Catalog Number:
bsm-60908R
Alternative Catalog Number:
BSS-BSM-60908R-100
Manufacturer:
Bioss
Host:
Rabbit
Category:
Antikörper
Application:
IF, IHC-Fr, IHC-P
Species Reactivity:
Human
Conjugation:
Unconjugated
Alternative Names:
IGHD, Constant region of heavy chain of IgD, Ig delta chain C region, Ig delta chain C region secreted form, Igh-5, Immunoglobulin delta, Immunoglobulin heavy constant delta, IGHD_HUMAN, Immunoglobulin heavy delta chain.
Ig delta chain C region is an allelic product of the human IGHD gene. The two known IGHD alleles, IGHD*01 and IGHD*02, respectively produce isoforms 1, a secreted protein, and 2, a single-pass type I membrane protein. A member of the adaptive immune system, IgD antibodies are monomers expressed by activated B cells. Containing 3 Ig-like (immunoglobulin-like) domains, IgD chain C is located on chromosome 14 within the human heavy chain locus, lying on the 3 side of the IgM chain C region from the V-D-J cassette. Polyadenylation at certain sites along the heavy chain locus likely effects the mechanism that determines the alternative splicing event which results in the expression of either IgD chain C or IgM chain C. Some studies have suggested that antigenic coactivation of IgD+ B cells can have a negative influence on bone resorption during infectious events.
