ADCP2, DPPIV, Dipeptidyl peptidase 4, ADABP, ADCP 2, Adenosine deaminase complexing protein 2, CD 26, CD26 antigen 3, Dipeptidyl peptidase 4, Dipeptidyl peptidase iv, Dipeptidylpeptidase 4, Dipeptidylpeptidase IV, DPP 4, DPP IV, DPP4, Intestinal dipeptidyl peptidase, T cell activation antigen CD26, TP 103, TP103, DPP4_HUMAN.
The DPP4 gene encodes dipeptidyl peptidase 4, which is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic type II transmembrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. Dipeptidyl peptidase 4 is highly involved in glucose and insulin metabolism, as well as in immune regulation. This protein was shown to be a functional receptor for Middle East respiratory syndrome coronavirus (MERS-CoV), and protein modeling suggests that it may play a similar role with SARS-CoV-2, the virus responsible for COVID-19. [provided by RefSeq, Apr 2020]
