SMG1 Recombinant Antibody, PE-Cy5 Conjugated, PE/Cy5, Rabbit

Product Overview

• Article Name: SMG1 Recombinant Antibody, PE-Cy5 Conjugated, PE/Cy5, Rabbit
• Biozol Catalog Number: BSS-BSM-62379R-PE-CY5
• Supplier Catalog Number: bsm-62379R-PE-Cy5
• Alternative Catalog Number: BSS-BSM-62379R-PE-CY5-100
• Manufacturer: Bioss
• Host: Rabbit
• Category: Antikörper
• Application: WB
• Species Reactivity: Human, Mouse, Rat
• Conjugation: PE/Cy5
• Alternative Names: 61E3.4, ATX, hSMG1, LIP, smg1.

Product Description

Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex.

Product Properties

• Clonality: Recombinant
• Concentration: Lot dependent
• NCBI: 23049
• UniProt: Q96Q15
• Buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
• Source: KLH conjugated synthetic peptide derived from human SMG1
• Target: SMG1

Application Notes

• Application Dilute: WB(1:300-5000)