Human CA9 Ready-To-Use IHC Kit

Product Overview

• Article Name: Human CA9 Ready-To-Use IHC Kit
• Biozol Catalog Number: BSS-IHC0199H
• Supplier Catalog Number: IHC0199H
• Alternative Catalog Number: BSS-IHC0199H-50
• Manufacturer: Bioss
• Category: Kits/Assays
• Species Reactivity: Human
• Alternative Names: CAIX, G250, MN, CA IX, CA-IX, Carbonic anhydrase 9, CAH9_HUMAN, Carbonate dehydratase IX, Carbonic anhydrase IX, Carbonic dehydratase, Membrane antigen MN, P54/58N, P54/58N, pMW1, RCC associated protein G250, RCC-associated antigen G250, Renal cell carcinoma associated antigen G250, Renal cell carcinoma-associated antigen G250.

Product Description

Carbonic anhydrase (CA) is an enzyme that assists rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions. It is abundant in all mammalian tissues. There are many genes that are inducible by hypoxia, via HIF-1 alpha. CA IX is one of the most inducible genes because of its stability and location within the membrane. Carbonic anhydrases have a widespread role in regulating pH in normal tissues, by regulating hydrogen ion (H+) flux. The pH is important in cell death under hypoxia, thus a blockade of CA IX results in increased cell death under hypoxia. Therefore, CA IX has become a reliable histochemical marker of hypoxia.

Product Properties

• Samples: FFPE tissue
• Target: Human CA9

Images

IHC0199H