BNSP, BSPI, ETA-1, OPN, PSEC0156, SPP1, Bone sialoprotein 1, BSP I, Early T lymphocyte activation 1, ETA 1, ETA1, MGC110940, Nephropontin, osteopontin, Secreted phosphoprotein 1, SPP 1, SPP-1, SPP1/CALPHA1 fusion, Urinary stone protein, Uropontin.
Osteopontin is an arginine-glycine-aspartic acid (RGD)-containing glycoprotein that interacts with integrins and CD44 as major receptors. It is a multifunctional protein involved in bone mineralization, cell adhesion, cell migration, chronic inflammatory disease and transformation. Proteolytic cleavage by thrombin and matrix metalloproteinases close to the integrin-binding Arg-Gly-Asp sequence modulates the function of OPN and its integrin binding properties. Thrombin-cleaved fragments of Osteopontin are overexpressed in malignant glial tumors and provide a molecular niche with survival advantage and provide a novel substrate for plasmin and cathepsin D
Samples:
FFPE tissue
Target:
Human Osteopontin
IHC0343H
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