Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate, different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably inthe context of PI3KC3-C2 (PubMed:20643123).
Samples:
FFPE tissue
Target:
Mouse PI3 kinase p150
IHC0434M
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