LEU-9, CD7, CD7 antigen (p41), CD7 molecule, CD7_HUMAN, T-cell antigen CD7, T-cell leukemia antigen, T-cell surface antigen Leu-9, CD 7, CD7 antigen, CD7 antigen p41, CD7 molecule, GP 40, GP40, LEU 9, LEU9, p41, p41 protein, T cell antigen CD7, T cell antigen CD7 precursor, T cell leukemia antigen, Tp 40, TP 41, Tp40, TP41a
CD7 (gp40, Leu9) is a 40 kDa member of the immunoglobulin gene superfamily. CD7 contains N-terminal amino acids 1-107 are highly homologous to Ig kappa-L chains whereas the carboxy-terminal region ofthe extracellular domain is proline-rich and has been postulated to form a stalk from which the Ig domain projects. CD7 is expressed on the majority of immature and mature T-lymphocytes, and T cell leukemia. Further, CD7 is also found on natural killer cells, a small subpopulation of normal B cells and on malignant B cells. Cross-linking surface CD7 positively modulates T cell and NK cell activityas measured by calcium fluxes, expression of adhesion molecules, cytokine secretion and proliferation. CD7 associates directly with phosphoinositol 3-kinase. CD7 ligation induces production of D-3 phosphoinositides and tyrosine phosphorylation. Expression of CD7 is an important marker used in leukemia diagnostics.
Samples:
FFPE tissue
Target:
Human CD7
IHC0501H
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