C-type lectin domain family 4 member K, CD207 antigen, langerin, C type lectin domain family 4 member K, CD 207, CD207, CD207 antigen, CD207 molecule, CLEC 4K, CLEC4K, Langerhans cell specific c type lectin, RGD1565913, CLC4K_HUMANa
Langerin (CD207) is a type II membrane-associated C-type lectin known to be expressed exclusively by Langerhans cells. Lamgerin recognizes mannose residues via its single carbohydrate recognition domain (CRD). Langerin is localized not only on the cell surface, but also intracellularly in close association with Birbeck granules. Transfection of Langerin cDNA into fibroblasts creates a compact network of membrane structures with typical features of Birbeck granules (BG). Langerin is thus a potent inducer of membrane superimposition and zippering leading to BG formation.
Samples:
FFPE tissue
Target:
Human CD207
IHC0517H
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