LRP, MVP, VAULT1, 2310009M24Rik, Lung Resistance Related Proteina
This gene encodes the major vault protein which is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences, however, the open reading frames are the same in both transcripts.
Samples:
FFPE tissue
Target:
Human LRP/MVP
IHC0580H
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