Oncogene TCL 1, Oncogene TCL1, Protein p14 TCL1, T cell leukemia/lymphoma 1A, TCL1, TCL1Aa
Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha or TCR-beta regulatory elements (summarized by Virgilio et al., 1998). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (Laine et al., 2000).
Samples:
FFPE tissue
Target:
Human TCL1A
IHC0584H
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