Human DCP1A Ready-To-Use IHC Kit

Product Overview

• Article Name: Human DCP1A Ready-To-Use IHC Kit
• Biozol Catalog Number: BSS-IHC0644H
• Supplier Catalog Number: IHC0644H
• Alternative Catalog Number: BSS-IHC0644H-50
• Manufacturer: Bioss
• Category: Kits/Assays
• Species Reactivity: Human
• Alternative Names: 1110066A22Rik, 4930568L04Rik, AU019772, D14Ertd817e, DCP1A, HSA275986, Mitc1, Nbla00360, DCP1 decapping enzyme homolog A, Dcp1a, DCP1A_HUMAN, mRNA decapping enzyme 1A, mRNA-decapping enzyme 1A, Smad4 interacting transcriptional co activator, Smad4-interacting transcriptional co-activator, Smad4-interacting transcriptional co-activator, SMAD4IP1, SMIF, Transcription factor SMIFa

Product Description

Signal transduction of TGF-beta superfamily members is regulated by Smad proteins. In particular, Smads influence specific gene transcription by relaying signals from the cell membrane to the nucleus. Smad4 plays an essential role in TGF-beta-induced transcriptional activation wherein phosphorylated receptor-associated Smads associate with Smad4. Furthermore, SMIF (Smad4-intereacting protein) and Smad4 complex with TGF-beta and BMP4. An increase in Smad4 concentration increases the translocation of this complex to the nucleus. SMIF and Smad4 interact directly through a EVH1/WH1 domain on SMIF and a proline-rich activation domain on Smad4. Smad4 is essential to nuclear translocation of SMIF as deletion of the Smad4-interacting domain (located in the N-terminal 100 amino acids) of SMIF eliminates TGF-beta-induced nuclear translocation of SMIF. The human SMIF gene is ubiquitously expressed and encodes a protein with a relative molecular mass of 70 kDa.

Product Properties

• Samples: FFPE tissue
• Target: Human DCP1A

Images

IHC0644H