Glia Maturation Factor beta (GMF-beta) is a 17 kDa brain specific protein that belongs to the ADF/cofilin superfamily. It is a neurotrophin that induces maturation of neurons and glial cells. Unlike other neurotrophins, GMF-beta lacks a leader sequence and can be phosphorylated by protein kinase A and protein kinase C suggesting its role in signal transduction. GMF-beta is a prominent mediator of inflammation in the central nervous system and can activate several inflammation-related genes such as tumor necrosis factor-alpha and interleukin-1beta. Researchers have shown there are significantly higher levels of GMF-beta protein in all the effected regions of Alzheimers disease (AD) brains suggesting an important role of GMF-beta in AD pathogenesisRecombinant human Glia Maturation Factor beta (rhGMF-beta) produced in E.coli is a single non-glycosylated polypeptide chain containing 142 amino acids. rhGMF-beta has a molecular mass of 16.7kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
Molecular Weight:
16.7 kDa, observed by reducing SDS-PAGE.
Source:
Escherichia coli.
Purity:
> 95% by SDS-PAGE and HPLC analyses.
Form:
Sterile Filtered White lyophilized (freeze-dried) powder.
