Chemokine (C-C motif) ligand 1 (CCL1), also known as I-309, is a small glycoprotein secreted by activated T cells that belongs to the family ofchemokines. Human CCL1 has been assumed to be a homologue of mouse TCA3. While the two proteins share only approximately 42% amino acid sequence identity, both chemokines contain an extra pair of cysteine residues not found in most other chemokines. CCL1 attracts monocytes, NK cells, immature B cells and dendritic cells by interacting with the cell surface chemokine receptor CCR8. This chemokine resides in a large cluster of CC chemokines on human chromosome 17.Recombinant Human I-309/CCL1 produced in E.coli is a single non-glycosylated polypeptide chain containing 74 amino acids. A fully biologically active molecule, rhI-309/CCL1has a molecular mass of 8.5 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.
Molecular Weight:
8.5 kDa, observed by reducing SDS-PAGE.
Source:
Escherichia coli.
Purity:
> 95% as analyzed by SDS-PAGE.
Form:
Sterile Filtered White lyophilized (freeze-dried) powder.
Sequence:
SKS MQVPFSRCCF SFAEQEIPLR AILCYRNTSS ICSNEGLIFK LKRGKEACAL DTVGWVQRHR KMLRHCPSKR K
Formula:
Lyophilized after extensive dialysis against PBS.
Application Notes:
Reconstituted in ddH2O or PBS at 100 µg/ml.
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