Sharing 79% sequence identity with human Tumor Necrosis Factor-alpha (hTNF-alpha), mouse Tumor Necrosis Factor-alpha (mTNF-alpha) is a cytokine mainly expressed by immune cells [1]. A type II transmembrane protein, TNF-alpha is further proteolytically processed to a soluble form [2]. The trimeric active TNF-alpha[3] then exerts its diverse biological properties including gapoptosis, inflammation, autoimmunity and cell proliferation by binding to TNF Receptor 1 and 2 [4]. Recombinant mouse Tumor Necrosis Factor-alpha (rmTNF-alpha) produced in P.pastoris is a fully biologically active polypeptide chain of 152 amino acids with a molecular mass of 17 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.
Molecular Weight:
17kDa, observed by reducing SDS-PAGE.
Source:
P. pastoris
Purity:
> 95% as analyzed by reducing SDS-PAGE.
Form:
Sterile Filtered White lyophilized (freeze-dried) powder.
