Synthetic peptide, corresponding to amino acids 61-110 of Human ERalpha.
Conjugation:
Unconjugated
Alternative Names:
Estrogen receptor, ER-alpha, ER, ESR1, ESR, NR3A1
Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ERalpha and ERbeta, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. ERalpha and ERbeta have been shown to be differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ERalpha and ERbeta may be regulated by distinct mechanisms even though they share many functional characteristics.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Form:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
