GANP (E1872) polyclonal antibody, Unconjugated, Rabbit

Product Overview

• Article Name: GANP (E1872) polyclonal antibody, Unconjugated, Rabbit
• Biozol Catalog Number: BWT-BS1138
• Supplier Catalog Number: BS1138
• Alternative Catalog Number: BWT-BS1138-50UL,BWT-BS1138-100UL
• Manufacturer: Bioworld Technology
• Host: Rabbit
• Category: Antikörper
• Application: IHC
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide, corresponding to amino acids 1841-1890 of Human GANP.
• Conjugation: Unconjugated
• Alternative Names: Germinal-center associated nuclear protein, 80 kDa MCM3-associated protein, MCM3 acetylating protein, MCM3 acetyltransferase, MCM3AP, GANP, KIAA0572, MAP80

Product Description

Minichromosome maintenance protein 3 (MCM3) is a protein essential for the initiation of DNA replication. MCM3-associated protein (MCM3AP), also known as GANP or MAP80, is a 1980 amino acid protein which binds to MCM3. MCM3AP is an acetyltransferase that acetylates MCM3, thereby playing an indirect role in DNA replication. MCM3AP is also believed to be involved in the nuclear localization of MCM3. Localized to the nucleus and the cytoplasm, GANP (MCM3AP) is thought to have phosphorylation-dependent DNA-primase activity that is up-regulated in germinal center regions. MCM3AP contains a nuclear localization signal, a coiled-coil structure and four LXXLL motifs.

Product Properties

• Molecular Weight: ~ 218 kDa
• UniProt: O60318
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
• Form: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Application Notes

• Application Dilute: IHC: 1:50~1:200
• Application Notes: GANP (E1872) polyclonal antibody detects endogenous levels of GANP protein.