Synthetic peptide, corresponding to the N-terminal of Human PML.
Conjugation:
Unconjugated
Alternative Names:
Protein PML, Promyelocytic leukemia protein, RING finger protein 71, Tripartite motif-containing protein 19, MYL, PP8675, RNF71, TRIM19
The PML protein is a zinc finger transcription factor expressed as three major transcription products due to alternative splicing. The gene encoding human PML maps to chromosome 15q22. The t(15,17) (q22,q11.2-q12) chromosomal trans-location of the retinoic acid receptor alpha (RARalpha) gene occurs in virtually all cases of acute promyelocytic leukemia and results in the expression of a PML/RARalpha chimeric protein. Myeloid precursor cells expressing the PML/ RARalpha chimera fail to differentiate and exhibit an increased growth rate consequent to diminished apoptosis. PML/RARalpha transforms myeloid precursors by recruiting the nuclear co-repressor (N-CoR)-histone deacetylase complex that is essential to retinoic acid-dependent myeloid differentiation. PML/ RARalpha also recruits DNA methyltransferases in order to induce gene hypermethylation and silencing, which ultimately facilitates leukemogenesis.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Form:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Dilute:
WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200
Application Notes:
PML (P39) polyclonal antibody detects endogenous levels of PML protein.
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