Ras (H27) polyclonal antibody, Unconjugated, Rabbit

Product Overview

• Article Name: Ras (H27) polyclonal antibody, Unconjugated, Rabbit
• Biozol Catalog Number: BWT-BS1309
• Supplier Catalog Number: BS1309
• Alternative Catalog Number: BWT-BS1309-50UL,BWT-BS1309-100UL
• Manufacturer: Bioworld Technology
• Host: Rabbit
• Category: Antikörper
• Application: IHC, WB
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide, corresponding to amino acids 1-50 of Human Ras.
• Conjugation: Unconjugated
• Alternative Names: GTPase HRas, H-Ras-1, Ha-Ras, Transforming protein p21, c-H-ras, p21ras, HRAS, HRAS1, GTPase NRas, Transforming protein N-Ras, NRAS, HRAS1, GTPase KRas, K-Ras 2, Ki-Ras, c-K-ras, c-Ki-ras, GTPase KRas, KRAS, KRAS2, RASK2

Product Description

The KRAS gene encodes the human cellular homolog of a transforming gene isolated from the Kirsten rat sarcoma virus. The RAS proteins are GDP/GTP-binding proteins that act as intracellular signal transducers. The most well-studied members of the RAS (derived from RAt Sarcoma virus) gene family include KRAS, HRAS, and NRAS. These genes encode immunologically related proteins with a molecular mass of 21 kD and are homologs of rodent sarcoma virus genes that have transforming abilities. While these wildtype cellular proteins in humans play a vital role in normal tissue signaling, including proliferation, differentiation, and senescence, mutated genes are potent oncogenes that play a role in many human cancers.

Product Properties

• Molecular Weight: ~ 21 kDa
• UniProt: P01112
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
• Form: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Application Notes

• Application Dilute: WB: 1:500~1:1000 IHC: 1:50~1:200
• Application Notes: Ras (H27) polyclonal antibody detects endogenous levels of total K-Ras, H-Ras and N-Ras proteins.