Synthetic peptide, corresponding to amino acids 501-550 of Human ERalpha.
Conjugation:
Unconjugated
Alternative Names:
Estrogen receptor, ER-alpha, ER, ESR1, ESR, NR3A1
Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor uperfamily of ligand-activated transcription factors. Estrogen receptors, ncluding ERalpha and ERbeta, contain DNA binding and ligand binding domains nd are critically involved in regulating the normal function of reproductive issues. ERalpha and ERbeta have been shown to be differentially activated by various igands. Receptor-ligand interactions trigger a cascade of events, including issociation from heat shock proteins, receptor dimerization, phosphorylation nd the association of the hormone activated receptor with specific regulatory lements in target genes. Evidence suggests that ERalpha and ERbeta may be egulated by distinct mechanisms even though they share many functional characteristics.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Form:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Dilute:
IHC: 1:50~1:200 IF: 1:50~1:200
Application Notes:
ER-alpha (K531) polyclonal antibody detects endogenous levels of ER-alpha protein.
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