MITF (G174) polyclonal antibody, Unconjugated, Rabbit

Product Overview

• Article Name: MITF (G174) polyclonal antibody, Unconjugated, Rabbit
• Biozol Catalog Number: BWT-BS1550
• Supplier Catalog Number: BS1550
• Alternative Catalog Number: BWT-BS1550-50UL,BWT-BS1550-100UL
• Manufacturer: Bioworld Technology
• Host: Rabbit
• Category: Antikörper
• Application: IF, WB
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide, corresponding to Human MITF.
• Conjugation: Unconjugated
• Alternative Names: Microphthalmia-associated transcription factor, Class E basic helix-loop-helix protein 32, bHLHe32

Product Description

Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to M-boxes (5-TCATGTG-3) and symmetrical DNA sequences (E-boxes) (5-CACGTG-3) found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.

Product Properties

• Molecular Weight: ~ 60-75 kDa
• UniProt: O75030
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
• Form: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Application Notes

• Application Dilute: WB: 1:500~1:2000 IF: 1:100~1:500
• Application Notes: MITF polyclonal antibody detects endogenous levels of MITF protein.