APRIL (S183) polyclonal antibody, Unconjugated, Rabbit
Biozol Catalog Number:
BWT-BS1893
Supplier Catalog Number:
BS1893
Alternative Catalog Number:
BWT-BS1893-50UL,BWT-BS1893-100UL
Manufacturer:
Bioworld Technology
Host:
Rabbit
Category:
Antikörper
Application:
IF, IHC, WB
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide, corresponding to amino acids 151-200 of Human APRIL.
Conjugation:
Unconjugated
Alternative Names:
Tumor necrosis factor ligand superfamily member 13, A proliferation-inducing ligand, APRIL, TNF- and APOL-related leukocyte expressed ligand 2, TALL-2, TNF-related death ligand 1, TRDL-1, TRDL1, CD256, TNFSF13, APRIL, TALL2, ZTNF2, ORF Names: UNQ383/PRO715
A proliferation-inducing ligand (APRIL), also designated TNFSF13, is a Type II membrane protein that shares characteristics with other members of the tumor necrosis factor (TNF) cytokine family. APRIL is expressed in high levels in transformed cell lines and in human colon, thyroid, and lymphoid tumor tissues. APRIL is critically involved in the regulation of infections, inflammation, autoimmune diseases, and tissue homeostasis. APRIL is implicated in the regulation of tumor cell growth. The C-terminal extracellular domain has b jelly roll topography and is important in ligand trimerization. The binding of the ligand to its respective receptor induces oligomerization, initiating downstream signaling events. Intrinsic to oligomerization is the formation of the receptor binding site at the junction between neighboring subunits, creating a multivalent ligand.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Form:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Dilute:
WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200
Application Notes:
APRIL (S183) polyclonal antibody detects endogenous levels of APRIL protein.
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