EAR2 (v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 2) protein binds a cis enhancer element (TGACCT motif) upstream of the rennin gene and represses renin gene transcription. EAR2 also contributes to gonadotropin-dependent derepression of LHR promoter activity in granulose cells. EAR2 mRNA is abundant in the liver, and EAR2 protein localizes to the nucleus of As4.1 cells.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Form:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Dilute:
WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200
Application Notes:
EAR2 (S40) polyclonal antibody detects endogenous levels of EAR2 protein.
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