Synthetic peptide, corresponding to amino acids 50-100 of Human Hel-N1.
Conjugation:
Unconjugated
Alternative Names:
ELAV like 4, ELAV like neuronal protein 1, ELAV like protein 2, ELAV like protein 4, ELAVL 2, ELAVL 4, HELN1, Hu antigen B, Hu antigen D, HUB, HUD, Hel-N1, ELAVL2, HEL-N1, HELN1, HUB
The Elav-like genes encode for a family of RNA-binding proteins. Elav, a Drosophila protein and the first described member, is expressed immediately after neuroblastic differentiation into neurons and is necessary for neuronal differentiation and maintenance. Several mammalian Elav-like proteins, designated HuC, HuD and Hel-N1, are also expressed in postmitotic neurons. An additional mammalian homolog, HuR, which is also designated HuA, is ubiquitously expressed and is also overexpressed in a wide variety of tumors. Characteristically, these homologs all contain three RNA recognition motifs (RRM), and they specifically bind to AU-rich elements (ARE) in the 3-untranslated region of mRNAs transcripts. ARE sites target mRNA for rapid degradation and thereby regulate the expression levels of genes involved in cell growth and differentiation.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Form:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Dilute:
IHC: 1:50~1:200
Application Notes:
Hel-N1 (N86) polyclonal antibody detects endogenous levels of HuB protein, and also detects HuD protein
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