The general transcription factor TFIIE consists of two subunits, alpha and beta, and plays essential roles in transcription.Structure-function studies indicate that TFIIE has three-winged helix (WH) motifs, with one in TFIIEalpha and two in TFIIEbeta. by binding to the clamp region of RNA polymerase II, TFIIEalpha-WH promotes the conformational change that transforms the promoter-bound inactive preinitiation complex to the active complex.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Form:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Dilute:
WB: 1:500~1:1000
Application Notes:
TFIIE-beta (K183) pAb detects endogenous levels of TFIIE-beta protein.
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