ACVR1B (G111) polyclonal antibody, Unconjugated, Rabbit

Product Overview

• Article Name: ACVR1B (G111) polyclonal antibody, Unconjugated, Rabbit
• Biozol Catalog Number: BWT-BS1988
• Supplier Catalog Number: BS1988
• Alternative Catalog Number: BWT-BS1988-50UL,BWT-BS1988-100UL
• Manufacturer: Bioworld Technology
• Host: Rabbit
• Category: Antikörper
• Application: IF, IHC
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide, corresponding to amino acids 100-150 of Human ACTR-IB.
• Conjugation: Unconjugated
• Alternative Names: Activin receptor type-1B, Activin receptor type IB, ACTR-IB, Activin receptor-like kinase 4, ALK-4, Serine/threonine-protein kinase receptor R2, SKR2, ACVR1B, ACVRLK4, ALK4

Product Description

Members of the transforming growth factor beta superfamily bind to a pair of transmembrane proteins, known as receptor types I and II, which contain serine/threonine kinases and associate to form a signaling complex. Activin has been shown to bind a heteromeric noncovalent complex, which consists of a type I receptor, ACTR-IA (also designated ACVRI and ALK-2) or ACTR-IB (also designated ALK-4 and SKR2), and a type II receptor, ACTR-IIA (also designated ACVR2A) or ACTR-IIB (also designated ACVR2B). Both receptor types are highly expressed in brain. The activin receptor family members are thought to mediate distinct effects on gene expression, cell differentiation, and morpho genesis in a dose dependent fashion.

Product Properties

• Molecular Weight: ~ 56 kDa
• UniProt: P36896
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
• Form: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Application Notes

• Application Dilute: IHC: 1:50~1:200 IF: 1:50~1:200
• Application Notes: ACTR-IB (G111) polyclonal antibody detects endogenous levels of ACTR-IB protein.