Synthetic peptide, corresponding to amino acids 100-150 of Human HNF4alpha.
Conjugation:
Unconjugated
Alternative Names:
Hepatocyte nuclear factor 4-alpha, HNF-4-alpha, Nuclear receptor subfamily 2 group A member 1, Transcription factor 14, TCF-14, Transcription factor HNF-4, HNF4A, HNF4, NR2A1, TCF14, Hepatocyte nuclear factor 4-gamma, HNF-4-gamma, Nuclear receptor subfamily 2 group A member 2, HNF4G, NR2A2, HNF4gamma, HNF-4gamma, HNF-4alpha
HNF-1 (alpha and beta), HNF-3 (alpha, beta and gamma), HNF-4 (alpha and gamma), and HNF-6 compose, in part, a homoeprotein family designated the Hepatocyte Nuclear Factor family. The various HNF-1 isoforms regulate transcription of genes in the liver as well as in other tissues such as kidney, small intestine and thymus. HNF-3alpha, HNF-3beta and HNF-3gamma regulate the transcription of numerous hepatocyte genes in adult liver. HNF-3alpha and HNF-3beta have also been shown to be involved in gastrulation events such as body axis formation. HNF-4alpha and HNF-4gamma have been shown to be important for early embryo development. HNF-4alpha is expressed in liver, kidney, pancreas, small intestine, testis and colon, and HNF-4gamma is expressed in each of these tissues except liver.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Form:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Dilute:
WB: 1:500~1:1000 IHC: 1:50~1:200
Application Notes:
HNF-4alpha/gamma (K127) polyclonal antibody detects endogenous levels of HNF-4alpha and HNF-4gamma protein.
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