CBP20 (R21) polyclonal antibody, Unconjugated, Rabbit

Product Overview

• Article Name: CBP20 (R21) polyclonal antibody, Unconjugated, Rabbit
• Biozol Catalog Number: BWT-BS2012
• Supplier Catalog Number: BS2012
• Alternative Catalog Number: BWT-BS2012-50UL,BWT-BS2012-100UL
• Manufacturer: Bioworld Technology
• Host: Rabbit
• Category: Antikörper
• Application: IF, IHC, IP, WB
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide, corresponding to amino acids N-terminus of Human CBP20.
• Conjugation: Unconjugated
• Alternative Names: Nuclear cap-binding protein subunit 2, 20 kDa nuclear cap-binding protein, Cell proliferation-inducing gene 55 protein, NCBP 20 kDa subunit, CBP20, NCBP-interacting protein 1, NIP1, NCBP2, CBP20, ORF Names: PIG55

Product Description

In eukaryotes, the majority of mRNAs have an m(7)G cap, which is added cotranscriptionally and plays a critical role in many aspects of mRNA metabolism. The effect of the cap on translation is mediated by the initiation factor eIF-4F, whereas the effect on pre-mRNA splicing involves a nuclear complex (CBC). CBC consists of two cap binding proteins, CBP20 and CBP80, which mediate the stimulatory functions of the cap in pre-mRNA splicing, 3 end formation and U snRNA export. The genes CBC1 and CBC2 encode CBP80 and CBP20, respectively. CBP80 comprises three domains, each containing a MIF4G domain. CBP20 has an RNAP fold and associates with the second and third domains of CBP80.

Product Properties

• Molecular Weight: ~ 18 kDa
• UniProt: P52298
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
• Form: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Application Notes

• Application Dilute: WB: 1:500~1:1000 IHC/IF: 1:50~1:200 IP: 1:10~1:100
• Application Notes: CBP20 (R21) polyclonal antibody detects endogenous levels of CBP20 protein.