Activity-dependent neuroprotector (ADNP), also designated activity-dependent neuroprotective protein, is a nuclear protein that functions as a putative transcription factor and may participate in normal growth and cancer proliferation. ADNP is a highly conserved vasoactive intestinal peptide (VIP) responsive gene that is expressed profusely in the brain (primarily cerebellum and cortex regions) and is crucial for brain formation and embryonic development. ADNP is also highly expressed in kidney, placenta, heart, skeletal muscle, breast, and colon cancer tissues. Studies indicate that neuroprotection by subpicomolar PACAP38 might be mediated partially by expression of ADNP. A correlation between brain injuries and elevated ADNP levels indicates a potential involvement of ADNP in an endogenous compensatory mechanism.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Form:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Application Dilute:
WB: 1:500~1:1000
Application Notes:
ADNP polyclonal antibody detects endogenous levels of ADNP protein.
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